Endocrine Abstracts

Introduction: X-linked adrenoleucodystrophy (XALD) is a progressive disorder affecting adrenal glands, testis, and myelin stability, that normally caused by mutations in ABCD1 (NM_000033) gene There is a failure of β-oxidation of fatty acids within peroxisomes due to reduced activity of very long chain acyl-CoA synthetase and can be diagnosed by the demonstration of elevated very long chain fatty acid.Case report: We report a case of a 32-y...

Objective: Most hypothyroid patients require an optimal dose of 1.6–1.8 μg/body weight (kg) of L-thyroxine to restore a normal TSH. Poor response to treatment can be due to malabsorption, drugs interaction and poor compliance. We conducted a test to determine the likely cause of persistent hypothyroidism in a coeliac patient despite taking supraphysiological doses of L-thyroxine (>1000 μg OD).Case...

We have earlier shown that treatment with gonadotropin releasing hormone antagonist blocked adrenocortical tumour progression through gonadotropin suppression in inhibin α/SV40 T-antigen (inhα/Tag) transgenic (TG) mice. Hereby, we investigated the molecular mechanisms underlying the GnRH antagonist (Cetrorelix acetate; GnRH-a) treatment induced potential antitumor effects on gonadal somatic cell and adrenocortical tumors in vivo and in vitro. In...

Background: Congenital hyperinsulinism (CHI) is the commonest cause of persistent hypoglycaemia and is due to the unregulated secretion of insulin from the pancreatic beta-cells. The role of gut hormones and dipeptidyl peptidase-4 (DPP-4) is currently unknown in patients with CHI.Aims: To evaluate the expression pattern of DPP-4 in focal and diffuse CHI.Method: Using intra-operative formalin-fixed paraffin embedded (FFPE) pancreati...

A 73 years old gentleman with a diagnosis of mesothelioma presented with symptoms typical of hypoglycaemia. Other than the expected abnormal chest signs there were no significant examination findings.Capillary glucose was unrecordable; lab testing confirmed serum glucose of 0.9 mmol/l. He had no history of diabetes mellitus or any medication that may induce hypoglycaemia. There was a slight rise in CRP and white cell count was elevated. There was no clin...

Background: Recently, there is evidence to suggest that altered vitamin D and calcium homeostasis may play a role in the development and control of type 2 DM. Objective: The aim of the current study was to evaluate the effect of vitamin D supplementation on glycemic control in type 2 DM patients.Material and Methods: This is a Randomized controlled clinical trial. The study trial passed through two phases. Phase one: screening of diabetic patients to est...

Medicago sativa plants are commonly used as green fodder. In this study, estrogen-like activity of ethanolic extract of Medicago sativa plants and its possible effects on serum biochemical metabolites in immature female rats were investigated. Crude extract of dried Medicago sativa plants was prepared in 90% ethanol using Soxhlet’s apparatus. Fifteen immature female rats were divided into 3 equal groups. Rats of groups A and B were given the extract at the dose of 250 (lo...

Introduction: Lymphocytic hypophysitis is a rare autoimmune disease predominantly affecting females in the antepartum and postpartum period. It is characterized by destruction and lymphocytic infiltration of predominantly adenohypophysis with various degrees of hypopituitarism. Posteriour pituitary gland involvement is rare but has been reported. We report a case of a 32 year old lady who presented with diabetes insipidus and hypoadrenalism.Case: A 32 year old lady complai...

ObjectiveMeasurement of insulin sensitivity has always been a key interest in the clinical investigation of Type 2 diabetes mellitus. Previous studies have shown good correlation between the Oral Glucose Insulin Sensitivity (OGIS) Model and the gold standard euglycaemic hyperinsulinaemic glucose clamp. This study is to describe OGIS as an index for insulin sensitivity derived from glucose-insulin model in a clinical setting.Methods468 non-diabetes patients and 224 ...

Introduction: Diabetes ketoacidosis (DKA) remains a significant cause of mortality and morbidity in patients with diabetes. We reviewed all DKA episodes occurring in a large inner city teaching hospital between January 1997 and December 2001.Methods: A retrospective chart analysis was performed on 108 episodes of DKA identified through hospital inpatients enquiry (HIPE). DKA was defined as the triad of hyperglycaemia, ketonuria and acidosis with pH<7.35. All patients ha...